Gender differences in neurotoxicity
Gender-related differences in susceptibility to chemical exposure to neurotoxicants have not received sufficient attention although a significant number of epidemiological studies on the neurodevelopmental effects of metal exposure has been published in the last twenty years, not many of them have . Reduced mptp neurotoxicity in striatum of the mutant mouse tottering michael r kilbourn,1 phillip sherman,1 and louise c abbott2 1division of nuclear medicine, department of internal medicine, university of michigan medical school,. Since hormonal receptor levels are thought to be related to gender differences in brain dissociate alcohol neurotoxicity from any differences preceding the .
Gender-related differences in susceptibility to chemical exposure to neurotoxicants have not received sufficient attention although a significant number of epidemiological studies on the . Gender differences versus sex differences gender, a social construct, is expressed in terms of masculinity and femininity it is defined by the way people perceive themselves and how they expect others to behave. Gender differences in neurotoxicity abstract neurotoxicity is damage to the structure and/or function of the peripheral and central nervous systems it is a common .
Gender differences in the neurotoxicity of metals in children april 2013 toxicology gender-related differences in susceptibility to chemical exposure to neurotoxicants have not received . Gender gap in alcohol consumption closes as women drink more – study the gap is closing as women’s alcohol consumption researchers found that differences between men and women in . Fda drug safety communication: fda review results in new warnings about using general anesthetics and sedation drugs in young children and pregnant women or gender differences faustino pj .
Pharmacokinetic gender-dependent differences in cytochrome p450-mediated drug metabolism, especially cyp3a4, and their clinical implications are increasingly apparent cyp3a4 seems to be the most important cyp isoform in both bioactivation and n-dechloroethylation of the alkylating prodrug . Lucio costa, professor, env and occ health sciences biography gender-differences in oxidative stress and neurotoxicity air pollution and autism related disorders. Characterizing the gender differences of multidrug-resistance peptide (mrp) transporter expression in mouse blood-brain interfaces authors katiria m flores , university of connecticut, storrs follow. Continuing our previous work in which we showed wide-ranging strain differences in mptp neurotoxicity in male mice among ten bxd recombinant inbred strains, we replicated our work in females from nine of the same strains mice received a single sc injection of 125mg/kg mptp or saline forty-eight .
Gender differences in neurotoxicity
Gender differences in alcohol-induced neurotoxicity and brain damage alfonso-loeches s(1), pascual m, guerri c author information: (1)department of cellular pathology, centro de investigación príncipe felipe, c/eduardo primo yúfera 3, valencia 46012, spain. Gender differences in alcohol’s effects on the brain for adolescents in alcohol recovery adolescent alcohol use and alcohol use disorders among adolescent constitute serious problems by grade 12, nearly 60 percent of adolescents have been drunk, and studies suggest that approximately 6 percent of adolescents have an alcohol use disorder. Recent human and animal studies suggest that gender dimorphic profiles are emerging in terms of neurotoxicity, moreover that gender differences in neurotoxicity are more widespread than one may expect.
This research is furthering our understanding of gender differences in sensitivity to these agents, and how these differences may relate to differences in incidence of parkinson’s and vascular disease between the sexes. The observed gender differences in the urinary excretion of mdma and its metabolites can be partly explained by the more rapid renal process in males, including clearance of drugs metabolized by cyp2d6 (schwartz, 2003) more studies with female subjects are needed to draw any further conclusions on gender differences in mdma metabolism.
The identification of these sex-dependent differences in markers provides a foundation for more exhaustive evaluation of their impact upon, and treatment of, disorders/neurotoxicity of the nigrostriatal dopaminergic system and the bases for the differences that exist between females and males. Sex differences in caffeine neurotoxicity following chronic ethanol exposure and withdrawal considering gender/sex when examining neuroadaptive changes in . Gender differences in the association of smoking and drinking with the development of cognitive impairment boyoung park ,. Gender differences non-genetic factors review of nmda antagonist-induced neurotoxicity and implications for clinical development if there are region .